Emergence of a New Creutzfeldt-Jakob Disease: 26 Cases of the Human Version of Mad-Cow Disease, Days After a COVID-19 Injection


  • Jean-Claude Perez Biomathematics; Luc Montagnier Foundation https://orcid.org/0000-0001-6446-2042
  • Claire Moret-Chalmin Neurology; Luc Montagnier Foundation
  • Luc Montagnier Virology; discoverer of the human immunodeficiency virus and Nobel Laureate 2008




Creutzfeldt-Jacob Disease, CJD, prion protein, SARS-COV-2 variants, spike protein, COVID-19 mRNA vaccines, COVID viruses, neurpsychiatric disease, evolution of the COVID virus


Creutzfeldt-Jakob Disease, the formerly rare but universally fatal prion disease in humans, normally progresses over several decades before it leads to death. In the Appendix to this paper, we highlight the presence of a prion region in the spike protein of the original SARS-CoV-2, and in all the “vaccine” variants built from the Wuhan virus. The prion region in the spike of SARS-CoV-2 has a density of mutations eight times greater than that of the rest of the spike, and, yet, strangely that entire prion region disappears completely in the Omicron variant. In the main body of our text, we present 26 cases of Creuzfeldt-Jacob Disease, all diagnosed in 2021 with the first symptoms appearing within an average of 11.38 days after a Pfizer, Moderna, or AstraZeneca COVID-19 injection. Because the causal progression, the etiopathogenesis, of these atypical and new cases of human prion disease — cases of what is apparently a totally new form of rapidly developing Creuzfeldt-Jacob Disease — we focus on the chronology of the symptomatic development. We consider it from an anamnestic point of view — one in which we compare the typical development of pre-COVID cases of Creuzfeldt-Jacob Disease to the extremely accelerated development of similar symptoms in the 26 cases under examination. By such an approach, we hope to work out the etiopathogenesis critical to understanding this new and much more rapidly developing human prion disease. By recalling the sequential pathway of that the formerly subacute and slowly developing disease followed in the past, and by comparing it with this new, extremely acute, rapidly developing prion disease — one following closely after one or more of the COVID-19 injections — we believe it is correct to infer that the injections caused the disease in these 26 cases. If so, they have probably also caused a many other cases that have gone undiagnosed because of their rapid progression to death. By late 2021, 20 had died within 4.76 months of the offending injection. Of those, 8 died suddenly within 2.5 months confirming the rapid progression of this accelerated form of Creuzfeldt-Jacob Disease. By June 2022, 5 more patients had died, and at the time of this current writing, only 1 remains still alive.

Author Biography

  • Luc Montagnier, Virology; discoverer of the human immunodeficiency virus and Nobel Laureate 2008

    Luc Montagnier, MD, and Nobel Laureate, esteemed colleague and friend, passed from this world on February 8, 2022 not long after the completion of the preliminary draft of this work which his co-authors have carried forward to this updated report with some additional cases and new information. Perhaps this may be the most important work of Luc’s lifetime expressing his incredible genius and spirit. While hospitalized, he continued to attach the greatest importance to the publication of this article. He is honored by the Luc Montagnier Foundation Quai Gustave-Ador 62 1207, Geneva, Switzerland.


Broudy, D., Bergman, T., & Ed Rankin. (2020, February 20). Telecom Jackboot: A 5G Kick to the Groin. OffGuardian. https://off-guardian.org/2020/02/20/telecom-jackboot-a-5g-kick-to-the-groin/

Classen, J. B. (2021a). COVID-19 RNA based vaccines and the risk of prion disease. Microbiology & Infectious Diseases, 5(1), 1–3. https://principia-scientific.com/covid-19-rna-based-vaccines-and-the-risk-of-prion-disease/

Classen, J. B. (2021b). US COVID-19 vaccines proven to cause more harm than good based on pivotal clinical trial data analyzed using the proper scientific endpoint, “all cause severe morbidity.” Trends in Internal Medicine, 1(1), 1–6. available here

Cohen, J. (2020). Wuhan coronavirus hunter Shi Zhengli speaks out. Science. https://science.sciencemag.org/content/369/6503/487.full

Doyer, M. (2021, October 31). Marc Doyer rejoint VERITY France. Verity-France. https://www.verity-france.org/marc-doyer-rejoint-verity-france/

Fleming, D. R. M. (2021). Is COVID-19 a Bioweapon? A Scientific and Forensic Investigation. Skyhorse. https://www.simonandschuster.com/books/Is-COVID-19-a-Bioweapon/Richard-M-Fleming/Children-s-Health-Defense/9781510770195

Green, A. J. (2019). RT-QuIC: A new test for sporadic CJD. Practical Neurology, 19(1), 49–55.

Haute-Garonne, S., Toulouse, & Haute-Garonne, Ps., Toulouse,. (2022, March 27). L’Inrae reconnaît que la technicienne toulousaine morte de Creutzfeldt-Jakob a été victime d’un accident de laboratoire [Inrae recognizes that the dead Toulouse technician from Creutzfeldt-Jakob was the victim of a laboratory accident]. ladepeche.fr. https://www.ladepeche.fr/2022/03/17/linrae-reconnait-que-la-technicienne-toulousaine-morte-de-creutzfeldt-jakob-a-ete-victime-dun-accident-de-laboratoire-10176126.php

Herrmann, U. S., Sonati, T., Falsig, J., Reimann, R. R., Dametto, P., O’Connor, T., Li, B., Lau, A., Hornemann, S., & Sorce, S. (2015). Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathogens, 11(2), e1004662. https://doi.org/10.1371/journal.ppat.1004662

Hu, B., Guo, H., Zhou, P., & Shi, Z.-L. (2020). Characteristics of SARS-CoV-2 and COVID-19. Nature Reviews Microbiology, 1–14. https://doi.org/10.1038/s41579-020-00459-7

Hughes, D. A. (2022). What is in the so-called COVID-19 “vaccines”? Part 1: evidence of a global crime against humanity. International Journal of Vaccine Theory, Practice, and Research, 2(2), 455–586. https://doi.org/10.56098/ijvtpr.v2i2.52

Idrees, D., & Kumar, V. (2021). SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. Biochemical and Biophysical Research Communications, 554, 94–98. https://doi.org/10.1016/j.bbrc.2021.03.100

Iwasaki, Y., Akagi, A., Mimuro, M., Kitamoto, T., & Yoshida, M. (2015). Factors influencing the survival period in Japanese patients with sporadic Creutzfeldt–Jakob disease. Journal of the Neurological Sciences, 357(1), 63–68. https://doi.org/10.1016/j.jns.2015.06.065

Kennedy, R. F., Jr. (2021). The Real Anthony Fauci: Bill Gates, Big Pharma, and the Global War on Democracy and Public Health. Skyhorse Publishing. https://www.simonandschuster.com/books/Thimerosal-Let-the-Science-Speak/Robert-F-Kennedy/9781632206015

Kushnirov, V. V., Kochneva-Pervukhova, N. V., Chechenova, M. B., Frolova, N. S., & Ter-Avanesyan, M. D. (2000). Prion properties of the Sup35 protein of yeast Pichia methanolica. The EMBO Journal, 19(3), 324–331.

Kuvandık, A., Özcan, E., Karaduman, S., & Sungurtekin, H. (2022). Creutzfeldt-Jakob Disease After the Coronavirus Disease-2019 Vaccination. Turkish Journal of Intensive Care, 20(1), 61–64. https://doi.org/10.4274/tybd.galenos.2021.91885

Kyrie, V., & Broudy, D. (2022a). Cyborgs R Us: The bio-nano panopticon of injected bodies? International Journal of Vaccine Theory, Practice, and Research, 2(2), 355–383. https://doi.org/10.56098/ijvtpr.v2i2.49

Kyrie, V., & Broudy, D. (2022b). The Covid-19 concoction: A recipe for successful psychological operations. Propaganda in Focus, 7901. https://propagandainfocus.com/the-covid-19-concoction-a-recipe-for-successful-psychological-operations/

Lancaster, A. K., Nutter-Upham, A., Lindquist, S., & King, O. D. (2014). PLAAC: A web and command-line application to identify proteins with prion-like amino acid composition. Bioinformatics, 30(17), 2501–2502. https://doi.org/10.1093/bioinformatics/btu310

Lazarus, R., Klompas, M., Bernstein, S., & Harvard Pilgrim Health Care, Inc. (2010). Electronic Support for Public Health–Vaccine Adverse Event Reporting System (ESP-VAERS) (p. 7). Harvard Pilgrim Health Care, Inc. https://healthit.ahrq.gov/sites/default/files/docs/publication/r18hs017045-lazarus-final-report-2011.pdf

Lemstra, A. W., Van Meegen, M. T., Vreyling, J. P., Meijerink, P. H. S., Jansen, G. H., Bulk, S., Baas, F., & Van Gool, W. A. (2000). 14-3-3 testing in diagnosing Creutzfeldt–Jakob disease: A prospective study in 112 patients. Neurology, 55(4), 514–516. https://n.neurology.org/content/55/4/514.short

Mandelbrot, B. (1975). Stochastic models for the Earth’s relief, the shape and the fractal dimension of the coastlines, and the number-area rule for islands. Proceedings of the National Academy of Sciences of the United States of America, 72(10), 3825–3828. https://doi.org/10.1073/pnas.72.10.3825

Mandelbrot, B. (1982). The Fractal Geometry of Nature. Times Books. https://www.goodreads.com/book/show/558059.The_Fractal_Geometry_of_Nature

Mandelbrot, B. (2010). Fractals and the art of roughness. (2010, July 6). https://www.youtube.com/watch?v=ay8OMOsf6AQ

Markov, A. A. (1971). Extension of the Limit Theorems of Probability Theory to a Sum of Variables Connected in a chain. In R. Howard (Ed.), Dynamic Probabilistic Systems, Volume 1: Markov Chains (p. Appendix B). John Wiley & Sons. Available here.

Mauro, V. P., & Chappell, S. A. (2014). A critical analysis of codon optimization in human therapeutics. Trends in Molecular Medicine, 20(11), 604–613. https://doi.org/10.1016/j.molmed.2014.09.003

McAlary, L., Plotkin, S. S., Yerbury, J. J., & Cashman, N. R. (2019). Prion-like propagation of protein misfolding and aggregation in Amyotrophic Lateral Sclerosis. Frontiers in Molecular Neuroscience, 12. https://doi.org/10.3389/fnmol.2019.00262

Montagnier, L. & RAIR Foundation USA (Directors). (2021, May 18). Nobel Prize Winner Prof. Dr. Luc Montagnier – COVID Vaccines Are Creating the Variants and Deaths. https://www.bitchute.com/video/TciZzrFDpMxf/

Montagnier, L., & World Freedom Alliance. (2021, November 10). Luc Montagnier: “They Are Not Vaccines, They Are Poisons” – Speech To The Luxembourg Parliament. World Freedom Alliance Australia. https://worldfreedomalliance.org/au/news/luc-montagnier-they-are-not-vaccines-they-are-poisons-speech-to-the-luxembourg-parliament/

Montagnier, L. & RAIR Foundation USA. (2021, May 18). Nobel Prize Winner Prof. Dr. Luc Montagnier – COVID Vaccines Are Creating the Variants and Deaths. https://www.bitchute.com/video/TciZzrFDpMxf/

Moore, M. (2021, August 2). Prion Research Suspended in France as Researcher Dies from Creutzfeldt-Jakob Disease. Gilmore Health News. https://www.gilmorehealth.com/prion-research-suspended-in-france-as-researcher-dies-from-creutzfeldt-jakob-disease/

Moret-Chalmin, C. T. (2022, March 24). The case of Doyer Mauricette and 9 Creutzfeldt-Jakob Cases in 2021. 16th World Congress on Controversies in Neurology (CONy), London. https://cony2022.comtecmed.com/

Nonaka, T., Masuda-Suzukake, M., Arai, T., Hasegawa, Y., Akatsu, H., Obi, T., Yoshida, M., Murayama, S., Mann, D. M. A., Akiyama, H., & Hasegawa, M. (2013). Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains. Cell Reports, 4(1), 124–134. https://doi.org/10.1016/j.celrep.2013.06.007

Oller, J. W. (2021). Weaponized Pathogens and the SARS-CoV-2 Pandemic. International Journal of Vaccine Theory, Practice, and Research, 1(2), 172–208. https://doi.org/10.56098/ijvtpr.v1i2.16

Orrú, C. D., Groveman, B. R., Hughson, A. G., Zanusso, G., Coulthart, M. B., & Caughey, B. (2015a). Rapid and sensitive RT-QuIC detection of human Creutzfeldt-Jakob disease using cerebrospinal fluid. MBio, 6(1), e02451-14. https://doi.org/10.1128/mBio.02451-14

Pellionisz, A. J. (2008). The principle of recursive genome function. The Cerebellum, 7(3), 348–359. https://doi.org/10.1007/s12311-008-0035-y

Pellionisz, A. J. (2012). The decade of fractogene: From discovery to utility—Proofs of concept open genome-based clinical applications. International Journal of Systemics, Cybernetics and Informatics, 17–28. www.junkdna.com/pellionisz_decade_of_fractogene.pdf

Perez, J.-C. (2009). Codex biogenesis—Les 13 codes de l’ADN [Codex Biogenesis—The 13 Codes of DNA. M. Pietteur. https://livre.fnac.com/a2711702/Jean-Claude-Perez-Codex-biogenesis-Les-13-codes-de-l-ADN

Perez, J.-C. (2015). Deciphering hidden DNA meta-codes-the great unification & Master Code of Biology. Journal of Glycomics & Lipidomics, 5(2), 1. https://www.academia.edu/download/38089944/17032-2153-0637-5-131.pdf

Perez, J.-C. (2017a). The Master Code of biology: From prions and prions-like invariants to the self-assembly thesis. Biomedical Journal of Scientific and Technical Research, 1(4), 001–002. https://www.academia.edu/download/64947989/BJSTR.MS.ID.000369.pdf

Perez, J.-C. (2017b). The “Master Code of Biology”: Self-assembly of two identical peptides beta A4 1-43 “Amyloid” in Alzheimer’s Diseases. Biomed J Sci & Tech Res, 1(4), 2017. https://www.academia.edu/download/65866200/BJSTR.MS.ID.000394.pdf

Perez, J.-C. (2021). SARS-CoV-2 variants and vaccines mRNA spikes Fibonacci numerical UA/CG metastructures. https://doi.org/10.20944/preprints202104.0034.v5

Perez, J.-C., Lounnas, V., & Montagnier, M. (2021). The Omicron variant breaks the evolutionary lineage of SARS-CoV-2 variants. International Journal of Research -GRANTHAALAYAH, 9(12), Article 12. https://doi.org/10.29121/granthaalayah.v9.i12.2021.4418

Perez, J.-C., & Montagnier, L. (2021). Six fractal codes of life from bioatoms atomic mass to chromosomes numerical standing waves: Three breakthroughs in astrobiology, cancers, and artificial intelligence. International Journal of Research–Granthaalayah, 9, 133–191, https://www.academia.edu/download/79821461/4332.pdf

Pharmaceutical Technology. (2022, October 3). Covid-19 Vaccination Tracker. Pharmaceutical Technology. https://www.pharmaceutical-technology.com/covid-19-vaccination-tracker/

Prusiner, S. B. (1997). The Nobel Prize in Physiology or Medicine 1997. NobelPrize.Org. https://www.nobelprize.org/prizes/medicine/1997/prusiner/facts/

Redshaw, M. (2022, April 11). Exclusive: Son Describes Mother’s Death After Moderna Shot • Children’s Health Defense. https://childrenshealthdefense.org/defender/exclusive-son-describes-mothers-death-moderna-shot/

Rhoads, D. D., Wrona, A., Foutz, A., Blevins, J., Glisic, K., Person, M., Maddox, R. A., Belay, E. D., Schonberger, L. B., & Tatsuoka, C. (2020). Diagnosis of prion diseases by RT-QuIC results in improved surveillance. Neurology, 95(8), e1017–e1026. https://n.neurology.org/content/95/8/e1017.abstract

Santé Publique France. (2021, December 2). Maladie de Creutzfeldt-Jakob [Creutzfeldt-Jakob Disease]. Santé Publique France. https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-infectieuses-d-origine-alimentaire/maladie-de-creutzfeldt-jakob

Santiago, D. (2022a). A partial answer to the question posed by David A. Hughes, Phd, in the article: “What is in the so-called COVID-19 ‘vaccines’? Part 1: evidence of a global crime against humanity.” International Journal of Vaccine Theory, Practice, and Research, 2(2), 587–594. https://doi.org/10.56098/ijvtpr.v2i2.56

Santiago, D. (2022b). Playing Russian Roulette with every COVID-19 injection: The deadly global game. International Journal of Vaccine Theory, Practice, and Research, 2(2), 619–650. https://doi.org/10.56098/ijvtpr.v2i2.36

Sarlangue, G., Devilleger, J., Trillaud, P., Fouchet, S., Taillasson, L., Catteau, G., & Zeneca, A. (2021). Projet Bluetooth Expérience X. http://fpoinsot.free.fr/Doc/Experience.pdf

Seneff, S., Kyriakopoulos, A. M., Nigh, G., & Mccullough, P. A. (2022). SARS-CoV-2 Spike Protein in the Pathogenesis of Prion-like Diseases. https://doi.org/10.22541/au.166069342.27133443/v1

Seneff, S., & Nigh, G. (2021). Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19. International Journal of Vaccine Theory, Practice, and Research, 2(1), 38–79. https://doi.org/10.56098/ijvtpr.v2i1.23

Seneff, S., Nigh, G., Kyriakopoulos, A. M., & McCullough, P. A. (2022). Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs. Food and Chemical Toxicology, 164, 113008. https://doi.org/10.1016/j.fct.2022.113008

Société, Toulouse, Haute-Garonne. (2022, December 9). Chercheuse morte de Creutzfeldt-Jakob: L’émotion à l’École nationale vétérinaire de Toulouse [Researcher dies of Creutzfeldt-Jakob: Emotion at the National Veterinary School of Toulouse]. ladepeche.fr. https://www.ladepeche.fr/2021/12/01/a-lecole-veterinaire-de-toulouse-dans-le-labo-ou-travaillait-la-technicienne-victime-de-la-maladie-de-creutzfeldt-jakob-9964416.php

Swarajya Staff. (2020, July 5). China: COVID-19 like virus from a bat-infested mine that caused severe pneumonia was sent to Wuhan lab in 2013. Swarajyamag. https://swarajyamag.com/insta/china-covid-19-like-virus-from-a-bat-infested-mine-that-caused-severe-pneumonia-was-sent-to-wuhan-lab-in-2013

Tetz, G., & Tetz, V. (2022). Prion-like domains in spike protein of SARS-CoV-2 differ across its variants and enable changes in affinity to ACE2. Microorganisms, 10(2), 280. https://doi.org/10.3390/microorganisms10020280

Young, M. J., O’Hare, M., Matiello, M., & Schmahmann, J. D. (2020). Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration? Brain, Behavior, and Immunity, 89, 601–603. https://doi.org/10.1016/j.bbi.2020.07.007




How to Cite

Emergence of a New Creutzfeldt-Jakob Disease: 26 Cases of the Human Version of Mad-Cow Disease, Days After a COVID-19 Injection. (2023). International Journal of Vaccine Theory, Practice, and Research , 3(1), 727-770. https://doi.org/10.56098/ijvtpr.v3i1.66

Similar Articles

1-10 of 56

You may also start an advanced similarity search for this article.