No Nanobots in Vaccines — Just Lipids on the Loose: Commentary on Lee and Broudy (2024), “Real-Time Self-Assembly of Stereomicroscopically Visible Artificial Constructs in Incubated Specimens of mRNA Products Mainly from Pfizer and Moderna: A Comprehensive Longitundinal Study”

Authors

  • Anne S. Ulrich Karlsruhe Institute of Technology

DOI:

https://doi.org/10.56098/7hsjff81

Keywords:

cholesterol, Comirnaty, Moderna, nanorobotics, optical microscopy, Pfizer, self-assembling structures, transfection, BNT162b2 vaccine, nanobots, mod mRNA transfection, cationic amphiphiles, solid lipid nanoparticles, nanoparticles, impurities in vaccines

Abstract

Lee and Broudy (2024) reported conspicuous microscopic objects in mRNA vaccines, which they interpreted as “nano-robots”. This is a misconception, because the wide range of different shapes can be readily explained in terms of self-assembling lipids (including cholesterol), as are used for transfection. Lipid nanostructures and their rearrangements will be discussed.

Author Biography

  • Anne S. Ulrich, Karlsruhe Institute of Technology

    Full Professor of Biochemistry, Institute of Organic Chemistry (IOC) and Institute of Biological Interfaces (IBG2) at the Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany, Tel +49 721 60843222, email: [email protected] (ORCID: https://orcid.org/0000-0001-5571-9483)

References

Bar-Ziv, R., & Moses, E. (1994). Instability and “Pearling” States Produced in Tubular Membranes by Competition of Curvature and Tension. Physical Review Letters, 73(10), 1392–1395. https://doi.org/10.1103/PhysRevLett.73.1392

Chen, S. P., & Blakney, A. K. (2024). Immune response to the components of lipid nanoparticles for ribonucleic acid therapeutics. Current Opinion in Biotechnology, 85, 103049. https://doi.org/10.1016/j.copbio.2023.103049

Fongaro, B., Campara, B., Moscatiello, G. Y., Luigi, A. D., Panzeri, D., Sironi, L., Bigini, P., Carretta, G., Miolo, G., Pasut, G., & Polverino De Laureto, P. (2023). Assessing the physicochemical stability and intracellular trafficking of mRNA-based COVID-19 vaccines. International Journal of Pharmaceutics, 644, 123319. https://doi.org/10.1016/j.ijpharm.2023.123319

Gote, V., Bolla, P. K., Kommineni, N., Butreddy, A., Nukala, P. K., Palakurthi, S. S., & Khan, W. (2023). A comprehensive review of mRNA vaccines. International Journal of Molecular Sciences, 24(3), Article 3. https://doi.org/10.3390/ijms24032700

Jiang, H., Sang, Y., Zhang, L., & Liu, M. (2018). Self-assembly and directed assembly. In K. Ariga & M. Ebara (Eds.), Materials Nanoarchitectonics (pp. 165–186). John Wiley & Sons, Ltd. https://doi.org/10.1002/9783527808311.ch9

Konikoff, F. M., Chung, D. S., Donovan,J. M., Small, D. M. & Carey, M. C., (1992). Filamentous, helical, and tubular microstructures during cholesterol crystallization from bile. Journal of Clinical Investigation, 90, 1155-1160, https://doi.org/10.1172%2FJCI115935

Lee, Y. M., & Broudy, D. (2024). Real-time self-assembly of stereomicroscopically visible artificial constructions in incubated specimens of mRNA products mainly from Pfizer and Moderna: A comprehensive longitudinal study. International Journal of Vaccine Theory, Practice, and Research, 3(2), 1180–1244. https://doi.org/10.56098/586k0043

Singh, A., Burke, T. G., Calvert, J. M., Georger, J. H., Herendeen, B., Price, R. R., Schoen, P. E., & Yager, P. (1988). Lateral phase separation based on chirality in a polymerizable lipid and its influence on formation of tubular microstructures. Chemistry and Physics of Lipids, 47(2), 135–148. https://doi.org/10.1016/0009-3084(88)90083-7

Unruh, T., Götz, K., Vogel, C., Fröhlich, E., Scheurer, A., Porcar, L., & Steiniger, F. (2024). Mesoscopic structure of lipid nanoparticle formulations for mRNA drug delivery: Comirnaty and drug-free dispersions. ACS Nano, 18(13), 9746–9764. https://doi.org/10.1021/acsnano.4c02610

Downloads

Published

2024-09-10

How to Cite

No Nanobots in Vaccines — Just Lipids on the Loose: Commentary on Lee and Broudy (2024), “Real-Time Self-Assembly of Stereomicroscopically Visible Artificial Constructs in Incubated Specimens of mRNA Products Mainly from Pfizer and Moderna: A Comprehensive Longitundinal Study”. (2024). International Journal of Vaccine Theory, Practice, and Research , 3(2), 1244.1-1244.10. https://doi.org/10.56098/7hsjff81

Similar Articles

1-10 of 50

You may also start an advanced similarity search for this article.